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Volume 17, Issue 3, March 2025

Articles

Combination therapy dramatically promotes remyelination 
Yawen Li, Pingping Li, Yixuan Song, Wenjun Zhang, Xinyue Jiang, Siyi Chen, Wei Luo, Caiyun Ma, Changqing Liu, Jianguo Niu, Aibin Liang, Yarui Du, Bo O Zhou, Mingliang Zhang
J Mol Cell Biol, Volume 17, Issue 3, March 2025, mjaf005, https://doi.org/10.1093/jmcb/mjaf005
Abstract | Full Text 
A nomogram to predict gestational diabetes mellitus: a multicenter retrospective study
Rui Zhang, Zhangyan Li, Nuerbiya Xilifu, Mengxue Yang, Yongling Dai, Shufei Zang, Jun Liu
J Mol Cell Biol, Volume 17, Issue 3, March 2025, mjaf008, https://doi.org/10.1093/jmcb/mjaf008
Abstract | Full Text 
Akt-elicited phosphorylation of Acapin steers cell migration
Chunyue Wang, Jiajia Zhou, Tao Li, Shihao Du, Tetsuro Urushidani, Dongmei Wang, Yong Chen, McKay Mullen, Xinwang Cao, Shi-Yuan Cheng, Xia Ding, Fengrui Yang, Xuebiao Yao
J Mol Cell Biol, Volume 17, Issue 3, March 2025, mjaf010, https://doi.org/10.1093/jmcb/mjaf010
Abstract | Full Text 
Silencing GGH induces autophagy by increasing folate stress and production of NADH
Yu Li, Yuhui Du, Sijie Chen, Zhangrong Xie, Xinrui Li, Baoyue Lin, Zhiqing Zhou, Huijie Zhao, Guoan Chen
J Mol Cell Biol, Volume 17, Issue 3, March 2025, mjaf014, https://doi.org/10.1093/jmcb/mjaf014
Abstract | Full Text 

Letters to the Editor

Characterization of the nucleolar localization signal of TRMT10A and its importance for the m1G9 methylation of tRNAs in mammalian cells
Tianyang Luo, Zhiyuan Shi, Haibin Yang, Jiafan Miao, Zilong Chang, Jie Zou, Qiang Zeng, Wenbin Wu, Yanan Jiang, Xiaoling Xie, Liu Cao, Hong Peng, Chunmei Li, Deyin Guo, Junyu Wu
J Mol Cell Biol, Volume 17, Issue 3, March 2025, mjaf011, https://doi.org/10.1093/jmcb/mjaf011
Abstract | Full Text 
Structural insights into CRL2FEM1C ubiquitin ligase-mediated protein ubiquitination
Hualin Zhou, Mor Israel-Gueta, Xinyan Chen, Qiong Guo, Xing Liu, Itay Koren, Chao Xu
J Mol Cell Biol, Volume 17, Issue 3, March 2025, mjaf016, https://doi.org/10.1093/jmcb/mjaf016
Abstract | Full Text 

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Cover: The cover portrays a combination therapy (CT) for demyelinating diseases, symbolized through Chinese mythology. Chang'e, the moon goddess (CLM), scatters delicate flowers—symbolizing the Shh, Egf, and Fgf17 signaling pathways— that stimulate the differentiation of oligodendrocyte progenitor cells (OPCs). In parallel, Wu Gang (αCD20), the relentless woodcutter, tirelessly chops at a tree, representing B cells that activate proinflammatory Th1/Th17 cells to secrete inflammatory cytokines such as IFN-γ, TNF-α, and IL-17. Through their harmonious synergy, this CT reshapes the immune microenvironment while promoting OPC differentiation and in situ remyelination. This hand-made image is graciously provided by Miss Ke Ye. See mjaf005 by Li et al. for details.