1Shenzhen Key Laboratory of Systems Medicine for Inflammatory Diseases, Centre for Infection and Immunity Study (CIIS), School of Medicine, Shenzhen Campus of Sun Yat-sen University, Shenzhen 518197, China 2Guangzhou National Laboratory, Guangzhou International Bio-Island, Guangzhou 510320, China. 3MOE Key Laboratory of Tropical Disease Control, Institute of Human Virology, Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. 4State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510182, China. *Correspondence to:Junyu Wu , Email:wujy68@mail.sysu.edu.cn Deyin Guo , Email:guodeyin@mail.sysu.edu.cn