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Volume 17, Issue 4, April 2025

Review

Beyond the ends: potential implications of telomeric repeat-containing RNA (TERRA) for CNS diseases 
Hadjer Namous, Raghu Vemuganti
J Mol Cell Biol, Volume 17, Issue 4, April 2025, mjaf013, https://doi.org/10.1093/jmcb/mjaf013
Abstract | Full Text 

Articles

Argon improves microglia-mediated hippocampal neuronal hyperexcitability to alleviate anxiety-like behaviors in mice 
Jie Cheng, Baiyang Zheng, Shusu Luo, Yuan Yuan, Xiaobo Wu, Zhenglin Jiang, Xia Li
J Mol Cell Biol, Volume 17, Issue 4, April 2025, mjaf006, https://doi.org/10.1093/jmcb/mjaf006
Abstract | Full Text 
The disruption of COPII vesicles activates HSF-1 through SEC-23
Zhidong He, Na Tang, Hao Liu, Xueqing Wang, Yue Yin, Chao Peng, Yidong Shen
J Mol Cell Biol, Volume 17, Issue 4, April 2025, mjaf017, https://doi.org/10.1093/jmcb/mjaf017
Abstract | Full Text 
The mechanoresponsive chromosomal passenger complex sustains furrow ingression under confinement
Chenxin Wang, Jingjing Ding, Chao Wang, Maiyong Zhang, Junjie Wu, Bowen Chen, Hui Yang, Ting Gang Chew
J Mol Cell Biol, Volume 17, Issue 4, April 2025, mjaf019, https://doi.org/10.1093/jmcb/mjaf019
Abstract | Full Text 

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Cover: The hippocampus plays a key role in mediating anxiety-related behaviors in mice after lipopolysaccharide (LPS) administration. In the presence of air, LPS activates hippocampal microglia, leading to increased proinflammatory cytokine release, neuronal hyperexcitability, and anxiety-like behaviors (fewer open-arm entries in the elevated plus maze). Conversely, treatment with argon significantly reduces microglial activation and cytokine production and thus alleviates anxiety-like behaviors in mice, suggesting a novel anti-neuroinflammatory pathway that may contribute to the anxiolytic effects of argon. See mjaf006 by Cheng et al. for details.