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Volume 17, Issue 1, January 2025

Review

Novel roles of ammonia in physiology and cancer 
Guantong Chen, Chenxi Wang, Shuo Huang, Shibo Yang, Qiyuan Su, Yige Wang, Weiwei Dai
J Mol Cell Biol, Volume 17, Issue 1, January 2025, mjaf007, https://doi.org/10.1093/jmcb/mjaf007
Abstract | Full Text 

Articles

Inhibition of EphA2 by syndecan-4 in wounded skin regulates clustering of fibroblasts
Rebecca Brooks, Xianhui Wei, Mang Leng Lei, Francisca Cisterna Cid, James A. Roper, Rosalind C. Williamson, Mark D. Bass
J Mol Cell Biol, Volume 17, Issue 1, January 2025, mjae054, https://doi.org/10.1093/jmcb/mjae054
Abstract | Full Text 
A long noncoding RNA with enhancer-like function in pig zygotic genome activation
Renyue Wei, Yanbin Yue, Yinhuan Wu, Chenyuan Zhang, Jun-Xue Jin, Zhonghua Liu, Jiaqiang Wang
J Mol Cell Biol, Volume 17, Issue 1, January 2025, mjae061, https://doi.org/10.1093/jmcb/mjae061
Abstract | Full Text 
ENO1–BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism
Zhikun Li, Kaixiang Fan, Caixia Suo, Xuemei Gu, Chuxu Zhu, Haoran Wei, Liang Chen, Ping Gao, Linchong Sun
J Mol Cell Biol, Volume 17, Issue 1, January 2025, mjaf001, https://doi.org/10.1093/jmcb/mjaf001
Abstract | Full Text 
Multivalent interactions of Septin 6 promote the establishment of epithelial cell polarity 
Weihong Fu, Xueying Wang, Mussarat Rafiq, Hengyi Shao, Cunyu Wang, Dongmei Wang, Changlu Tao, Chuanhai Fu, Barbara Zieger, Xing Liu, Xuebiao Yao, Liangyu Zhang
J Mol Cell Biol, Volume 17, Issue 1, January 2025, mjaf003, https://doi.org/10.1093/jmcb/mjaf003
Abstract | Full Text 

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Cover: In healthy skin, the interaction between EphA2 and ephrinA1 on the surfaces of colliding fibroblasts triggers the activation of contractile signals, causing the cells to move apart and scatter. However, upon injury, the wound sensor syndecan-4 is upregulated, suppressing EphA2 expression through a PKCα-dependent pathway. As a result, syndecan-4 reduces EphA2 signalling and fibroblast repulsion, allowing fibroblasts to cluster in the wound bed and drive wound contraction. See mjae054 by Brooks et al. for details.