Cancer biology and the related translational researches are among the topics of the most interest to the life science society, including the general audience of JMCB. Several issues of JMCB have been published to report the progresses in various areas of cancer biology (Wu, 2013a, b, 2015). This issue includes more research papers presenting new molecular factors involved in either positive or negative regulation of tumorigenesis, which might contribute to developing new biomarkers or intervention targets for cancer therapy.