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Volume 8, Issue 5, October 2016

Editorial

New factors involved in tumorigenesis Free
Jiarui Wu
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 371-371, https://doi.org/10.1093/jmcb/mjw039
Abstract | Full Text 

Articles

miR-5003-3p promotes epithelial-mesenchymal transition in breast cancer cells through Snail stabilization and direct targeting of E-cadherin Free
Seo-Young Kwak, Je-Ok Yoo, Hyun-Ju An, In-Hwa Bae, Myung-Jin Park, Joon Kim, and Young-Hoon Han
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 372-383, https://doi.org/10.1093/jmcb/mjw026
Abstract | Full Text 
microRNA-129-5p, a c-Myc negative target, affects hepatocellular carcinoma progression by blocking the Warburg effect Free
Han Han, Wenjuan Li, Hongxing Shen, Jinxiang Zhang, Yahui Zhu, and Youjun Li
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 400-410, https://doi.org/10.1093/jmcb/mjw010
Abstract | Full Text 
TIP60 inhibits metastasis by ablating DNMT1−SNAIL2-driven epithelial-mesenchymal transition program Free
Yanzhou Zhang, Vanitha Krishna Subbaiah, Deepa Rajagopalan, Cheng Yong Tham, Lissa Nurrul Abdullah, Tan Boon Toh, Min Gong, Tuan Zea Tan, Shweta Pradip Jadhav, Amit Kumar Pandey, Neerja Karnani, Edward Kai-Hua Chow, Jean Paul Thiery, and Sudhakar Jha
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 384-399,
Abstract | Full Text 
Structure of the TBC1D7–TSC1 complex reveals that TBC1D7 stabilizes dimerization of the TSC1 C-terminal coiled coil region Free
Zhongchao Gai, Wendan Chu, Wei Deng, Wenqi Li, Hua Li, Ailiang He, Mark Nellist, and Geng Wu
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 411-425, https://doi.org/10.1093/jmcb/mjw001
Abstract | Full Text 
Interleukin-38 is released from apoptotic cells to limit inflammatory macrophage responses Free
Javier Mora, Andrea Schlemmer, Ilka Wittig, Florian Richter, Mateusz Putyrski, Ann-Christin Frank, Yingying Han, Michaela Jung, Andreas Ernst, Andreas Weigert, and Bernhard Brüne
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 426-438, https://doi.org/10.1093/jmcb/mjw006
Abstract | Full Text 
Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells Free
Andrew M. Tilston-Lünel, Kathryn E. Haley, Nicolas F. Schlecht, Yanhua Wang, Abigail L.D. Chatterton, Susana Moleirinho, Ailsa Watson, Harinder S. Hundal, Michael B. Prystowsky, Frank J. Gunn-Moore, and Paul A. Reynolds
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 439-455, https://doi.org/10.1093/jmcb/mjw020
Abstract | Full Text 

Letters to the Editor

K259-SUMOylation of DGCR8 promoted by p14ARF exerts a tumor-suppressive function Free
Changhong Zhu, Cheng Chen, Ran Chen, Rong Deng, Xian Zhao, Hailong Zhang, Jinzhuo Duo, Qin Chen, Hui Jin, Yanli Wang, Jian Huang, Ming Xu, and Jianxiu Yu
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 456-458, https://doi.org/10.1093/jmcb/mjw030
Abstract | Full Text 
Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1 Free
Rong Wang, Zhijing Wang, Kaikai Wang, Tianlong Zhang, and Jianping Ding
J Mol Cell Biol, Volume 8, Issue 5, October 2016, 459-461, https://doi.org/10.1093/jmcb/mjw033
Abstract | Full Text 

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Cover: miR-5003-3p promotes EMT by acting in a dual manner: Snail stabilization by targeting of MDM2 and direct targeting of E-cadherin. This dual mechanism and the mutual negative loop between Snail and E-cadherin can amplify the cellular response towards EMT and metastasis, highlighting a high potential of miR-5003-3p as a future target for anti-metastasis therapy. The background shows the metastatic foci in the lung from the mouse injected with miR-5003-3p-transfected cells by H&E staining. See pages 372–383 by Kwak et al. for details.