1MOE Key Laboratory for Cellular Dynamics and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. 2Anhui Key Laboratory for Chemical Biology and New Quality Medicine, Hefei National Research Center for Physical Sciences at the Microscale, Hefei 230027, China. 3Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China. *Correspondence to:Xing Liu , Email:xing1017@ustc.edu.cn Hongwu Qian , Email:qianhw@ustc.edu.cn