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Volume 16, Issue 6, June 2024

Articles

HSD17B13 liquid–liquid phase separation promotes leukocyte adhesion in chronic liver inflammation
Jing Ye, Xiyu Huang, Manman Yuan, Jinglin Wang, Ru Jia, Tianyi Wang, Yang Tan, Shun Zhu, Qiang Xu, Xingxin Wu
J Mol Cell Biol, Volume 16, Issue 6, June 2024, mjae018, https://doi.org/10.1093/jmcb/mjae018
Abstract | Full Text 
Single-cell analysis defines LGALS1+ fibroblasts that promote proliferation and migration of intrahepatic cholangiocarcinoma
Qiqi Cao, Jinxian Yang, Lixuan Jiang, Zhao Yang, Zhecai Fan, Shuzhen Chen, Sibo Zhu, Lei Yin, Hongyang Wang, Wen Wen
J Mol Cell Biol, Volume 16, Issue 6, June 2024, mjae023, https://doi.org/10.1093/jmcb/mjae023
Abstract | Full Text 
Phase separation of SPIN1 through its IDR facilitates histone methylation readout and tumorigenesis
Yukun Wang, Yuhan Chen, Mengyao Li, Jiayue Wang, Yuhan Jiang, Rong Xie, Yifeng Zhang, Zhihua Li, Zhenzhen Yan, Chen Wu
J Mol Cell Biol, Volume 16, Issue 6, June 2024, mjae024, https://doi.org/10.1093/jmcb/mjae024
Abstract | Full Text 
Blockade of TNF-α/TNFR2 signalling suppresses colorectal cancer and enhances the efficacy of anti-PD1 immunotherapy by decreasing CCR8+T regulatory cells
Yixian Guo, Feng Xie, Xu Liu, Shouyu Ke, Jieqiong Chen, Yi Zhao, Ning Li, Zeyu Wang1, Gang Yi, Yanying Shen, Dan Li, Chunchao Zhu, Zizhen Zhang, Gang Zhao, Hong Lu, Bin Li, Wenyi Zhao
J Mol Cell Biol, Volume 16, Issue 6, June 2024, mjad067, https://doi.org/10.1093/jmcb/mjad067
Abstract | Full Text 

Research Advance

Unleashing the power of antigen-presenting neutrophils
Yingcheng Wu, Jiaqiang Ma, Qiang Gao
J Mol Cell Biol, Volume 16, Issue 6, June 2024, mjae034, https://doi.org/10.1093/jmcb/mjae034
Abstract | Full Text 

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Cover: During chronic liver disease, such as metabolic dysfunction-associated steatohepatitis, human HSD17B13 homodimers form liquid–liquid phase separation (LLPS) in the liver, which promotes the biosynthesis of platelet activating factor (PAF) and activates the PAFR/STAT3 pathway to increase fi brinogen expression in hepatocytes, resulting in enhanced leukocyte adhesion and chronic liver infl ammation. See mjae018 by Ye et al. for details.