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Volume 15, Issue 6, June 2023

Reviews

Extracellular and intracellular functions of coiled-coil domain containing 3
Sara Omari, Hyemin Lee, Jieqiong Wang, Shelya X. Zeng, Hua Lu
J Mol Cell Biol, Volume 15, Issue 6, June 2023, mjad037, https://doi.org/10.1093/jmcb/mjad037
Abstract | Full Text 
Large-scale data-driven and physics-based models offer insights into the relationships among the structures, dynamics, and functions of chromosomes
Cibo Feng, Jin Wang, Xiakun Chu
J Mol Cell Biol, Volume 15, Issue 6, June 2023, mjad042, https://doi.org/10.1093/jmcb/mjad042
Abstract | Full Text 

Articles

A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells
Lei Tan, Xiaohua Duan, Pratyusha Mutyala, Ting Zhou, Sadaf Amin, Tuo Zhang, Brian Herbst, Gokce Askan, Tomer Itkin, Zhaoying Xiang, Fabrizio Michelassi, Michael D. Lieberman, Christine A. Iacobuzio-Donahue, Steven D. Leach, Todd Evans, Shuibing Chen
J Mol Cell Biol, Volume 15, Issue 6, June 2023, mjad039, https://doi.org/10.1093/jmcb/mjad039
Abstract | Full Text 
Targeted gene panel provides advantages over whole-exome sequencing for diagnosing obesity and diabetes mellitus
Hairong Yu, Haoyong Yu, Rong Zhang, Danfeng Peng, Dandan Yan, Yunjuan Gu, Yuqian Bao, Weiping Jia, Hong Zhang, Cheng Hu
J Mol Cell Biol, Volume 15, Issue 6, June 2023, mjad040, https://doi.org/10.1093/jmcb/mjad040
Abstract | Full Text 
Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis
Ran Liu, Zhen Dou, Tian Tian, Xinjiao Gao, Lili Chen, Xiao Yuan, Chunyue Wang, Jiahe Hao, Ping Gui, McKay Mullen, Felix Aikhionbare, Liwen Niu, Guoqiang Bi, Peng Zou, Xuan Zhang, Chuanhai Fu, Xuebiao Yao, Jianye Zang, Xing Liu
J Mol Cell Biol, Volume 15, Issue 6, June 2023, mjad041, https://doi.org/10.1093/jmcb/mjad041
Abstract | Full Text 

Letters to the Editor

Effective therapy of the small-molecule cocktail 5SM on adult rat heart after ischemia–reperfusion injury
Lixia Zheng, Yuanyuan Chen, Zhengyuan Wu, Xiaojun Zhu, Jing-Wei Xiong
J Mol Cell Biol, Volume 15, Issue 6, June 2023, mjad034, https://doi.org/10.1093/jmcb/mjad034
Abstract | Full Text 
PML–LRIF1 interactions form a novel link between promyelocytic leukemia bodies and centromeres
Junying Li, Xiao Yuan, Fengrui Yang, Jun Cao, Chunyue Wang, Saima Akram, Peng Zou, Felix Aikhionbare, Xuejun Li, Yong Chen, Liangyu Zhang, Chuanhai Fu, Zhikai Wang, Xing Liu, Xuebiao Yao
J Mol Cell Biol, Volume 15, Issue 6, June 2023, mjad038, https://doi.org/10.1093/jmcb/mjad038
Abstract | Full Text 

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Cover: Highly condensed chromosomes are intricately organized in the cell nucleus to underpin the desired gene expression. Four aspects of current chromosome modeling strategies are illustrated by this image (bubbles at top, left to right: data-driven and physics-based 3D structure modeling; bubbles at bottom, left to right: data-driven and physics-based 4D dynamics modeling). The key points of these approaches include incorporating experimental information into coarse-grained models, mechanistic modeling of molecular-level processes, and invoking the energy landscape theory as a framework. Ultimately, the theoretical work aims to unravel the complex structure-function relationships of chromosomes and explore potential applications in future genome engineering. See mjad042 by Feng et al. for details.