Letter to the Editor

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Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development Free
Xue Han 1,† , Sai Luo 1,5,† , Guangdun Peng 2,† ,J. Yuyang Lu 1 , Guizhong Cui 2 , Lichao Liu 1 ,Pixi Yan 1 , Yafei Yin 1 , Wei Liu 1 , Ran Wang 2 ,Jiejie Zhang 3 , Shanshan Ai 3 , Zai Chang 4 ,Jie Na 1 , Aibin He 3 , Naihe Jing 2, * ,and Xiaohua Shen 1, *
1 Tsinghua-Peking Center for Life Sciences,School of Medicine, Tsinghua University,Beijing 100084, China
2 State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China
3 Peking Center for Life Sciences, Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Peking University, Beijing 100871, China
4 School of Life Sciences, Tsinghua University,Beijing 100084, China
5 Present address: Program in Cellular and Molecular Medicine, Boston Children’s Hospital; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
These authors contributed equally to this work.
*Correspondence to:Xiaohua Shen, E-mail:xshen@tsinghua.edu.cn; Naihe Jing, E-mail:njing@sibcb.ac.cn
J Mol Cell Biol, Volume 10, Issue 2, April 2018, 175-178,  https://doi.org/10.1093/jmcb/mjy003

Dear Editor,

In mammalian genomes, pervasive transcription produces thousands of long noncoding RNA (lncRNA) transcripts (Djebali et al., 2012; Hon et al., 2017). Compared to protein-coding mRNAs, lncRNAs are less conserved, and often exhibit low-level, developmental stage- and tissue-specific expression (Pauli et al., 2011; Hu et al., 2012; Lee, 2012; Ulitsky and Bartel, 2013; Cech and Steitz, 2014; Hon et al., 2017). Many lncRNAs are strongly correlated with their neighboring mRNA genes in terms of expression and function, and tend to regulate nearby transcription (Orom et al., 2010; Engreitz et al., 2016;...