Shifting in balance between osteogenesis and adipogenesis substantially influences hematopoiesis Free
Ryohichi Sugimura 1 and Linheng Li1,2,*
1Stowers Institute for Medical Research, 1000 E. 50th Street, Kansas City, MO 64110 USA 2Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA *Correspondence to:Linheng Li, E-mail: lil@stowers.org
Adipocytes have been viewed as a space-filler in bone marrow for a long time. However, a recent study shows that adipocytes are microenvironmental components that suppress hematopoiesis under homeostatic and especially stressed conditions.