Renal involvement occurs frequently among patients with coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and acute kidney injury (AKI) is associated with poor prognosis and mortality of COVID-19. The potential mechanisms of AKI include direct virulence of SARS-CoV-2 and indirect mechanisms such as hyperinflammation, hypercoagulation, and unspecific kidney injury factors (Gabarre et al., 2020). The existence of infective SARS-CoV-2 in kidney has been verified providing a definite evidence of renal tropism and direct invasion of SARS-CoV-2 (Braun et al., 2020). Ascertaining the mechanism of SARS-CoV-2 entry will pave the way for preventing the infection and even tackling this epidemic.