Adipose (fat) tissues contain white, brown, and beige adipocytes. White adipocytes store extra energy in the form of lipids; ectopic and excessive accumulation of white adipose in the body leads to overweight and obesity, which often causes insulin resistance and Type 2 diabetes. Brown adipocytes, in contrast, contain hundreds of mitochondria per cell, dissipate energy into heat, and are negatively correlated to body weight and insulin resistance (Wu et al., 2013). Under cold temperature or β-adrenergic drug stimulation, a population of ‘beige’ or ‘brite’ adipocytes can be formed in the subcutaneous white adipose, containing intermediate levels of mitochondria and consume energy (Wu et al., 2013; Ye et al., 2013). Both brown and beige adipocytes are considered as good fats; and expansion or activation of these types of adipocytes thus represents a novel therapeutic strategy against obesity and diabetes.