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Janus kinase 2: an epigenetic 'writer' that activates leukemogenic genes Free
Jin He and Yi Zhang*
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7295, USA *Correspondence to:Yi Zhang, E-mail: yi_zhang@med.unc.edu
J Mol Cell Biol, Volume 2, Issue 5, October 2010, 231-233,  https://doi.org/10.1093/jmcb/mjp054

Activation of Janus kinase 2 (JAK2) plays a critical role in normal hematopoiesis and leukemogenesis. Dawson et al. (2009; JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461, 819-922) report that JAK2 performs this function by displacing the heterochromatin protein HP1伪 from chromatin through phosphorylation of histone H3.

Volume 2, Issue 5
October 2010