Department of Biochemistry, La Trobe University, Kingsbury Drive, Melbourne, VIC 3086, Australia *Correspondence to:W. Wei-Lynn Wong, E-mail: l.wong@latrobe.edu.au; John Silke, E-mail: j.silke@latrobe.edu.au
Ubiquitylation of caspase-8 by the Cullin3 E3 ligase allows its translocation to cytosolic aggregates in the cell by p62/sequestosome-1, increasing caspase-8 activation and thus leading to TRAIL-induced cell death.
