1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China 2Department of Clinic Immunology, The Third Affiliated Hospital at Sun Yat-sen University, Guangzhou 510630, China 3Division of Rheumatology, Department of Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA †These authors contributed equally to this work *Correspondence to:Song Guo Zheng , Email:szheng1@hmc.psu.edu Yehong Zhuo , Email:zhuoyh@mail.sysu.edu.cn