1State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031, China 2University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, China 3Unilever Research & Development Centre Shanghai, Shanghai 200335, China 4Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China 5School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China 6Key Laboratory of Systems Health Science of Zhejiang Province, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China 7Guangdong Institute of Intelligence Science and Technology, Zhuhai 519031, China †These authors contributed equally to this work. *Correspondence to:Xuelan Gu , Email:Xuelan.Gu@unilever.com Tao Zeng , Email:zengtao@sibs.ac.cn Luonan Chen , Email:lnchen@sibs.ac.cn