Advanced Search

Submit Online

Articles

< Previous         Next >  
A positive feedback regulatory loop involving the lncRNA PVT1 and HIF-1α in pancreatic cancer
Yiping Zhu1 , Fang Wu2 , Weiwei Gui3 , Nan Zhang2 , Erik Matro3 , Linghua Zhu1 , Daniel Turunen Eserberg3 , Xihua Lin2,4,*
1Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2Department of Endocrinology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
3School of Medicine, Zhejiang University, Hangzhou, China
4Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China
*Correspondence to:Xihua Lin , Email:linxihua@zju.edu.cn
J Mol Cell Biol, Volume 13, Issue 9, September 2021, 676-689,  https://doi.org/10.1093/jmcb/mjab042
Keyword: PVT1, HIF-1α, pancreatic cancer, feedforward regulatory loop
Extreme hypoxia is among the most prominent pathogenic features of pancreatic cancer (PC). Both the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and hypoxic inducible factor-1α (HIF-1α) are highly expressed in PC patients and play a crucial role in disease progression. Reciprocal regulation involving PVT1 and HIF-1α in PC, however, is poorly understood. Here, we report that PVT1 binds to the HIF-1α promoter and activates its transcription. In addition, we found that PVT1 could bind to HIF-1α and increases HIF-1α post-translationally. Our findings suggest that the PVT1‒HIF-1α positive feedback loop is a potential therapeutic target in the treatment of PC.

Volume 13, Issue 9
September 2021