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Volume 16, Issue 4, April 2024

Review

Chromothripsis: an emerging crossroad from aberrant mitosis to therapeutic opportunities
Umer Ejaz, Zhen Dou, Phil Y. Yao, Zhikai Wang, Xing Liu, Xuebiao Yao
J Mol Cell Biol, Volume 16, Issue 4, April 2024, mjae016, https://doi.org/10.1093/jmcb/mjae016
Abstract | Full Text 

Articles

Synergistic regulation of fusion pore opening and dilation by SNARE and synaptotagmin-1
Kaiju Li, Kaiyu Li, Jiaqi Fan, Xing Zhang, Chengyan Tao, Yijuan Xiang, Lele Cui, Hao Li, Minghan Li, Yanjing Zhang, Jia Geng, Ying Lai
J Mol Cell Biol, Volume 16, Issue 4, April 2024, mjae011, https://doi.org/10.1093/jmcb/mjae011
Abstract | Full Text 
Inhibition of GLUD1 mediated by LASP1 and SYVN1 contributes to hepatitis B virus X protein-induced hepatocarcinogenesis
Hong-Juan You, Qi Li, Li-Hong Ma, Xing Wang, Huan-Yang Zhang, Yu-Xin Wang, En-Si Bao, Yu-Jie Zhong, De-Long Kong, Xiang-Ye Liu, Fan-Yun Kong, Kui-Yang Zheng, Ren-Xian Tang
J Mol Cell Biol, Volume 16, Issue 4, April 2024, mjae014, https://doi.org/10.1093/jmcb/mjae014
Abstract | Full Text 
Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3
Miao Wang, Xiao-Wei Li, Sen-Chao Yuan, Jie Pan, Zeng-Lin Guo, Li-Ming Sun, Shao-Zhen Jiang, Ming Zhao, Wen Xue, Hong Cai, Lin Gu, Dan Luo, Ling Chen, Xue-Qing Zhou, Qiu-Ying Han, Jin Li, Tao Zhou, Tian Xia, Tao Li
J Mol Cell Biol, Volume 16, Issue 4, April 2024, mjae015, https://doi.org/10.1093/jmcb/mjae015
Abstract | Full Text 
The FAcilitates Chromatin Transcription complex regulates the ratio of glycolysis to oxidative phosphorylation in neural stem cells
Yuhan Lou, Litao Wu, Wanlin Cai, Huan Deng, Rong Sang, Shanshan Xie, Xiao Xu, Xin Yuan, Cheng Wu, Man Xu, Wanzhong Ge, Yongmei Xi, Xiaohang Yang
J Mol Cell Biol, Volume 16, Issue 4, April 2024, mjae017, https://doi.org/10.1093/jmcb/mjae017
Abstract | Full Text 

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Cover: Under autoimmune conditions, activated IRF3 molecules (the child holding a torch) are transported from the cytoplasm into the nucleus (the walls and gate representing the nuclear membrane and nuclear pore, respectively) to initiate the transcription of Type I interferons (the fi recrackers). Indomethacin can effectively inhibit the nuclear translocation of IRF3 (the closed gate labelled ‘no entry’), demonstrating a novel mechanism of indomethacin in controlling Type I interferon expression and its potential in treating autoimmune diseases. See mjae015 by Wang et al. for details.