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Volume 14, Issue 5, May 2022

Research Highlight

The putative mechanism of lymphopenia in COVID-19 patients
Xinling Wang, Zezhong Liu, Lu Lu, Shibo Jiang
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac034, https://doi.org/10.1093/jmcb/mjac034
Abstract | Full Text 

Reviews

Heart failure with preserved ejection fraction (HFpEF) in type 2 diabetes mellitus: from pathophysiology to therapeutics
Miyesaier Abudureyimu, Xuanming Luo, Xiang Wang, James R. Sowers, Wenshuo Wang, Junbo Ge, Jun Ren, Yingmei Zhang
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac028, https://doi.org/10.1093/jmcb/mjac028
Abstract | Full Text 
The multifaceted functions of cGAS
Haipeng Liu, Fei Wang, Yajuan Cao, Yifang Dang, Baoxue Ge
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac031, https://doi.org/10.1093/jmcb/mjac031
Abstract | Full Text 

Articles

Structural insights reveal the specific recognition of meiRNA by the Mei2 protein
Siyuan Shen, Yanze Jian, Zhaokui Cai, Fudong Li, Mengqi Lv, Yongrui Liu, Jihui Wu, Chuanhai Fu, Yunyu Shi
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac029, https://doi.org/10.1093/jmcb/mjac029
Abstract | Full Text 
NRF1-mediated microglial activation triggers high-altitude cerebral edema
Xueting Wang, Guijuan Chen, Baolan Wan, Zhangji Dong, Yan Xue, Qianqian Luo, Dan Wang, Yapeng Lu, Li Zhu
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac036, https://doi.org/10.1093/jmcb/mjac036
Abstract | Full Text 

Research Advance

Autocrine motility factor receptor as a therapeutic target for asthma: comments on ‘AMFR drives allergic asthma development by promoting alveolar macrophage-derived GM-CSF production’
Huihui Zhang, Feng Qian, Lei Sun
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac032, https://doi.org/10.1093/jmcb/mjac032
Abstract | Full Text 
Comments on ‘FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics’
Yujing Yin, Dengqiu Xu, Yan Mao, Zhenji Gan
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac033, https://doi.org/10.1093/jmcb/mjac033
Abstract | Full Text 
Hyperactivity of a midbrain dopamine to 5-HT circuit causes anorexia
Hailan Liu, Xing Cai, Yanlin He, Yong Xu
J Mol Cell Biol, Volume 14, Issue 5, May 2022, mjac035, https://doi.org/10.1093/jmcb/mjac035
Abstract | Full Text 

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Cover: Autocrine motility factor receptor (AMFR) regulates asthmatic inflammation by promoting the production of granulocyte-macrophage colony-stimulating factor (GM-CSF), leading to recruitment, accumulation, and activation of eosinophils and T helper 2 cells in the airway. Under thymic stromal lymphopoietin (TSLP) stimulation, AMFR, whose expression is upregulated in alveolar macrophages, directly binds to and destabilizes cytokine-inducible SH2-containing protein (CIS), resulting in augmented activation of STAT5 and GM-CSF production. See mjac032 by Zhang et al. for details.